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1113,50 This rationale underpins the development of dual GLP-1/GIP receptor agonists, which have been proposed as super-GLP-1 receptor agonists because of GIPs capacity of GIP to potentiate GLP-1 effects

GLP-1 signaling reduces appetite and improves insulin sensitivity

Another GLP-1/GIP/glucagon receptor triagonist known as retatrutide (previously LY3437943) was developed by Eli Lilly in 2022 leading to weight loss, reduced fat mass, decreased blood glucose and insulin levels in obese mice, which was attributed to increased energy expenditure and lipid oxidation [62]

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